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Sildenafil is really a strong and selective inhibitor of cGMP-unique phosphodiesterase style 5 (PDE5), that is chargeable for degradation of cGMP during the corpus cavernosum. The molecular framework of sildenafil is similar to that of cGMP and acts to be a competitive binding agent of PDE5 from the corpus cavernosum, resulting in more cGMP and amp